Journal article
Proximal weakness and creatine kinase elevation in systemic sclerosis: Clinical correlates, prognosis and functional implications
JL Fairley, D Hansen, J Day, S Proudman, J Sahhar, GS Ngian, J Walker, LV Host, K Morrisroe, W Stevens, L Ross, M Nikpour
Seminars in Arthritis and Rheumatism | W B SAUNDERS CO-ELSEVIER INC | Published : 2024
Abstract
Objectives: To determine the frequency, clinical correlates and implications of clinical evidence of muscle disease in systemic sclerosis (SSc). Methods: Australian Scleroderma Cohort Study participants with ≥1 creatine kinase (CK) and proximal power assessment were subdivided according to presence of proximal weakness (PW: proximal muscle power<5/5) and CK elevation(≥140IU/L). Participants were assigned to one of four groups: concurrent PW&CK elevation, PW alone, CK elevation alone or neither. Between-group comparisons were made with chi-squared, ANOVA or Kruskal-Wallis tests. Survival analysis was performed using time-varying-covariate Cox regression modelling. Longitudinal data were model..
View full abstractGrants
Awarded by St. Vin- cent's Hospital Melbourne IT Department and Research Endowment Fund (REF)
Awarded by NHMRC Investigator Grant
Awarded by RACP Australian Rheumatology Association & D.E.V. Starr Research Establishment Fellowship & Melbourne Medical School Strategic Grant for Outstanding Women
Funding Acknowledgements
The Australian Scleroderma Cohort Study (ASCS) is supported by Janssen, Boehringer Inelheim, Scleroderma Australia, Scleroderma Victoria, Arthritis Australia, Musculoskeletal Australia (muscle, bone and joint health) , Australian Rheumatology Association and St. Vin- cent's Hospital Melbourne IT Department and Research Endowment Fund (REF) . JLF holds a NHMRC Postgraduate Scholarship GNT2013842 an Australian Government Research Training Program Scholarship and the University of Melbourne John Hayden Research Fellowship. KM holds NHMRC Investigator Grant GTN1197169. LR is the recipient of a RACP Australian Rheumatology Association & D.E.V. Starr Research Establishment Fellowship & Melbourne Medical School Strategic Grant for Outstanding Women. MN holds an NHMRC Investi- gator Grant (GNT1176538) . JD holds a Sylvia and Charles Viertel Charitable Foundation Clinical Investigator Award, the John T Reid Charitable Trust Centenary Fellowship, the RACP-ARA D.E.V Starr Research Establishment Fellowship and the Victor Hurley Grant in Aid.